An equine bivalent F(ab')2 antivenom developed against the venoms of two neglected pit viper species from Northeast India-Trimeresurus erythrurus and T. popeiorum-exhibits enhanced in vitro and preclinical neutralisation efficacy when compared to Indian commercial polyvalent antivenom.
In north-east India (NEI), Trimeresurus erythrurus and T. popeiorum cause numerous snakebite fatalities; however, Indian polyvalent antivenom (PAV) against the big four venomous snakes exhibits weak neutralising efficacy. To address this gap, a bivalent equine F(ab')2 antivenom (Bi-AV) for the first time was developed...