M. Fallahi-Sichani

Mechanistic modeling reveals a configurable AP-1 network governing cell-state heterogeneity and adaptive plasticity in melanoma cells.

AP-1 transcription factors have been implicated in cellular plasticity, differentiation-state heterogeneity, and phenotype switching, enabling adaptation to anti-cancer therapies. Although AP-1 states, defined by the combinatorial expression of AP-1 proteins, are heterogeneous within cell populations, only a subset of...