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Author

M. Fernandez

2 papers indexed here

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Open access Aug 2026

Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia

Although polygenic burden contributes to variability in cognitive trajectories, its added predictive value beyond routinely available clinical variables remains modest.

B. Calm, Adrián Hinojosa-Calleja, F. García-Gutiérrez et al. · 0 citations
Open access Aug 2026

Alzheimer’s disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism

Specific AD-SNPs enriched in immune-brain axis pathways rather than Aβ related processes, were associated with reduced volumes of CA1 and subiculum prior to dementia onset, which supports that AD-PRS may capture genetic susceptibility to concomitant neurodegenerative diseases frequently misdiagnosed as AD.

C. Olivé, I. de Rojas, Linda Zhang et al. · 0 citations

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