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Oct 2026

Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression.

OBJECTIVE Subcallosal cingulate (SCC) deep brain stimulation (DBS) has shown promise for treatment-resistant depression. This study retrospectively evaluated a large curated SCC-DBS dataset to identify connectomic factors associated with sustained clinical improvement across patients, focusing on the white matter bundl...

Ha Neul Song, K. Choi, B. Kopell et al. · 1 citation
Open access Aug 2026

Reduced Left vmPFC-STN-Related White Matter Integrity Is Associated with Pre-Surgical Apathy in Parkinson's Disease.

Clinical significant apathy in PD prior to STN-DBS is associated with reduced white matter integrity in the left internal capsule involving the broader left-sided vmPFC projection system, which may contribute to future optimization of apathy management with STN-DBS.

Jip de Bruin, B. Kopell, H. Mayberg et al. · 0 citations

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