Abstract Background Alcohol Use Disorder (AUD) is one of the most prevalent psychiatric conditions and represents a major public health burden worldwide. Despite available pharmacotherapies, including naltrexone (NTX)—a mu-opioid receptor (MOR) antagonist—therapeutic efficacy remains limited due to side effects and sig...
M. Flores-Gómez, N. Cantero-García, J. P. Pineda-Gómez et al.· International Journal of Neu...· 0 citations
Background Alcohol Use Disorder (AUD) is a psychiatric condition whose severity can be amplified by social factors, such as social isolation, particularly during adolescence, which exacerbates development of AUD in adulthood. Our previous studies have demonstrated that the Galanin (1–15) fragment [GAL (1–15)] reduces a...
M. Flores-Gómez, N. Cantero-García, J. P. Pineda-Gómez et al.· Frontiers in Pharmacology· 0 citations
This study demonstrates that GAL(1–15) significantly enhances FLX’s antidepressant efficacy in a treatment-resistant depression model, and supports a synergistic interaction between galanin and serotonergic systems involving GALR2 and 5-HT1A receptor modulation, particularly within the PFC.
J. P. Pineda-Gómez, C. Millón, N. Cantero-García et al.· International Journal of Neu...· 0 citations
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