Abstract B025: A spatial proximity-weighted algorithm (SPAN) defines reproducible tumor niches and a persister ecosystem underlying acquired resistance to pan-RAS inhibition in PDAC
Spatial transcriptomics extends single-cell analysis of the tumor microenvironment into a mappable ecosystem by resolving gene expression in situ. Within it, cells assemble into recurrent multicellular niches whose spatial organization shapes tumor progression, immune evasion, and therapy response and resistance. Yet...