Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, microplastic and nanoplastic particles (MNPs) can translocate from the gut to internal organs1-3, with macrophages serving as primary targets4. Kupffer cells (KCs), the liver-resident macrophages, have a central ro...
Nikola Makdissi, Maria Francesca Viola, L. Steinheuer et al.· Nature Metabolism· 0 citations
Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label‐free proteomic profiling predicted changes in Ras homology family (RHO)‐signaling...
Jens Wagner, Henrike Antony, C. Hoyer et al.· Glia· 0 citations
DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.· Nature Neuroscience· 1 citation
ZenReg, an open-source Python platform that formulates common 2D+t, 3D, and 3D+t microscopy registration tasks as modular, geometry-preserving alignment problems, turns motion correction into an inspectable, memory-aware, and FAIR-oriented component of reproducible bioimage analysis.
By separating reusable analysis logic from project-specific configuration, CellColoc offers an extensible foundation for community-driven microscopy workflows that need transparent per-cell overlap classification, morphology readouts, and reusable batch analysis.
F. Musacchio, Henrike Antony, Arush Baijal et al.· bioRxiv· 1 citation
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