Sep 2026
Dishevelled drives disassembly of primary cilia through an unusual PDZ domain-mediated binding mode with Girdin-L.
Dishevelled is a pivotal cytoplasmic hub protein that transmits Wnt signals to various downstream effectors to specify cell fates and behaviors during animal development. The PDZ domain of Dishevelled is dispensable for signaling to β-catenin but essential for multiple evolutionarily conserved β-catenin-independent Wnt...
M. Renko, Gonzalo J. Beitia, Trevor J. Rutherford et al.
· Science Signaling · 0 citations