Open access
Jul 2026
Mechanism for Aromatic Nitration Catalyzed by Cytochrome P450 Enzymes from Rufomycin Biosynthesis
These experiments revealed the intimate and necessary involvement of a histidine residue within the pentapeptide substrate of RufO in supporting effective nitration, with the protonation state of the intermediate compound II proposed to influence the production of nitrated tyrosine over unwanted nitrate formation.
Alicia M. Kirk, Jemma Gullick, Yong-Wei Zhao et al.
· Journal of the American Chem... · 2 citations