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Open access Jul 2026

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Treatment application of Pep19‐2.5 via the nasal aerosol route reduces IL‐1β levels, eosinophil infiltration in bronchoalveolar lavage and significantly improved lung function in an in vivo HDM‐mouse model of allergic airway inflammation.

Jonas Engelhardt, Nico Kirsch, Aileen Kerfin et al. · 0 citations
Jul 2026

Abstract A053: Discovery and modular design of CDK12–DDB1 molecular glues for targeted Cyclin K degradation

Advanced lead molecules across these series achieve a rare combination of high CDK12/13 selectivity, potent and durable cyclin K degradation, and favorable physicochemical, in vitro ADME, and in vivo PK properties, supporting progression toward IND-enabling preclinical safety evaluation.

Thiyagamurthy Pandurangan, Anna Iermolaieva, Pompom Ghosh et al. · 0 citations

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