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Author

M. Giannakis

2 papers indexed here

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Sep 2026

Abstract B096: Immune and stromal features of durable complete response to radiation and dual immune checkpoint blockade in pancreatic cancer

Microsatellite stable (MSS) pancreatic ductal adenocarcinoma (PDAC) is refractory to immune checkpoint blockade, reflecting an immunosuppressive stroma, impaired lymphocyte trafficking, and low neoantigen burden. We conducted a single-arm phase II trial (NCT04361162) combining nivolumab, ipilimumab and radiation ther...

Sarah Kang, M. Parikh, Leontios Pappas et al. · 0 citations
Open access Sep 2026

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability–high (MSI-H) tumors. Although RNF43659mut promotes tumor growth through phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) activation independent...

Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel et al. · 0 citations

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