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M. Giménez

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Review Open access Sep 2026

Methodological challenges in surgical randomized trials: systematic review of rectal cancer studies

Abstract Background Surgical randomized clinical trials (RCTs) have structural features that differ fundamentally from those of non-surgical trials, which may complicate appraisal using standard assessment frameworks. This methodological systematic review used rectal cancer surgery RCTs as a high-complexity exemplar to...

D. Kitaguchi, M. Giménez, A. Forgione et al. · 0 citations

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