Open access
Aug 2026
WISP1 Drives Intestinal Fibrosis in Crohn's Disease via Metabolic and Rho/ROCK/MRTF-mediated cytoskeletal Remodeling.
BACKGROUND & AIMS Intestinal fibrosis remains a debilitating complication of Crohn's disease (CD). Canonical WNT signaling and WNT1 inducible signaling pathway protein (WISP1) are linked to tissue remodeling, but their role in intestinal fibrosis remains unclear. This study aims to elucidate how WISP1 regulates fibrobl...
A. Buck, Chiara Writz, Max Umbach et al.
· Gastroenterology · 0 citations