Author

M. Gutierrez

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Open access Oct 2026

Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution.

Visualizing when and where Mycobacterium tuberculosis (Mtb) genes are expressed in the host cell is crucial to understand tuberculosis heterogeneity. However, imaging approaches for studying spatiotemporal gene expression in Mtb remain limited. Here, we developed a dual-fluorophore Mtb reporter system that enables high...

Beren Aylan, Laure Botella, Pierre Santucci et al. · Cell Reports Methods · 0 citations

Open access Sep 2026

DFCP1-containing ER microdomains mediate lysosomal membrane repair

Lysosomal membrane integrity is essential for preserving cellular homeostasis in response to different stressors. Upon lysosomal membrane permeabilization, cells activate several mechanisms for lysosomal membrane repair, including ESCRT proteins, phosphatidylinositol 4-phosphate (PI4P)-dependent lipid transfer from the...

Maja Radulovic, S. Pust, Athanasios Kournoutis et al. · Nature Cell Biology · 2 citations

Open access Jul 2026

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

It is shown that LRRK2 G2019S has an effect during lysosomal damage through kinase-dependent and kinase-independent mechanisms, and isogenic induced pluripotent stem cells from patients carrying the LRRK2 G2019S variant confirmed that LRRK2 G2019S macrophages are more susceptible to cell death in a kinase-independent m...

Rebecca Morrison, Simeon R. Mihaylov, Chak-Hon Luk et al. · Journal of Cell Science · 1 citation