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M. H. Y. Cheng

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Open access Sep 2026

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency.

Lipid nanoparticles (LNPs) are the leading platform for delivery of RNA-based therapeutics. There is considerable interest in optimizing the transfection potency of these systems. Standard formulation protocols involve mixing lipids in ethanol with a buffer containing mRNA at pH 4, followed by dialysis against a pH 7.4...

Yao Zhang, Jerry Leung, Judy Cheng et al. · 0 citations

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