Author

M. Halić

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Open access Oct 2026

PARP1 directly disassembles nucleosomes to regulate DNA repair.

Upon DNA damage, chromatin remodeling is rapidly initiated to promote chromatin accessibility. Although this enhanced accessibility has been linked to poly(ADP-ribose) polymerase (PARP) activity, how cells overcome the nucleosome barrier remains unclear. We discovered that PARP1 directly and asymmetrically evicts histo...

Ashish Verma, Chang-Lei Zhu, Bernadette Truong et al. · Molecules and Cells · 0 citations

Open access Oct 2026

Transcription factor interactions promote binding to non-cognate DNA sites

Recruitment of transcription factors (TFs) to non-cognate DNA sequences is widely observed, but the underlying mechanisms remain poorly understood. Here, we show that, within the nucleosome, Sox2 can bind an Oct4 motif, interact with the Oct4 POU-specific domain, and displace the Oct4 homeodomain. We also observe Sox2...

Yong-Ming Du, Yin-Xia Yan, M. Halić · bioRxiv · 0 citations