Author

M. Handoko

3 papers indexed here

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Sep 2026

Longitudinal proteomic organ-specific aging in heart failure.

BACKGROUND Heart failure (HF) is a systemic syndrome affecting multiple organs. Organ age gaps (OAGs), quantifying organ-level aging from plasma proteomics, are linked to organ-specific disease including HF but have been studied exclusively cross-sectionally. We examined how organ-specific aging evolves within individu...

K. Qu, E. Diez-Benavente, Ezgi Hatip Ünlü et al. · European Journal of Heart Fa... · 0 citations

Review Open access Sep 2026

Heart failure with a preserved ejection fraction: synergy between cardiac and extracardiac mechanisms and effects of novel therapies

Heart failure with preserved ejection fraction (HFpEF) is a systemic disease in which metabolic comorbidities obesity, type 2 diabetes (T2D), and chronic kidney disease (CKD) converge to drive systemic inflammation, endothelial dysfunction, and myocardial fibrosis. Microvascular dysfunction represents an important link...

S. Nassiri, M. Handoko, A. A. van de Bovenkamp et al. · Heart Failure Reviews · 0 citations

Open access Aug 2026

Noninvasive Diagnosis of Heart Failure With Preserved Ejection Fraction Using the Left Atrioventricular Coupling Index.

BACKGROUND Right heart catheterization is the gold standard for diagnosing heart failure with preserved ejection fraction but is invasive and not readily accessible. The left atrioventricular coupling index (LACI), defined as the ratio of left atrial minimal volume to left ventricular end-diastolic volume, has been pro...

C. Janssen-Telders, J. Abele, L. Meijboom et al. · Journal of the American Hear... · 0 citations