Open access
Jul 2026
Systemic administration of all-trans retinoic acid modulated circulating immune cells but failed to improve healing in a preclinical model of musculoskeletal trauma
The effects of ATRA on peripheral blood immune cells both in vitro and in vivo using a rodent model of bone and muscle trauma revealed that a specific subset of MDSCs were depleted by systemic ATRA administration, and healing overall was not altered by ATRA treatment.
Tyler Guyer, Dylan Gill, K. Leguineche et al.
· Frontiers in Immunology · 0 citations