Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development.
Parafibromin/CDC73 is a multifunctional nuclear scaffold protein with context-dependent roles in tumorigenesis, functioning as both a tumor suppressor and an oncogenic driver. Originally identified as the product of the HRPT2 tumor suppressor gene, which is mutated in hyperparathyroidism-jaw tumor syndrome, Parafibromi...