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Open access Oct 2026

Absorption, distribution, metabolism and excretion of londamocitinib after single-dose inhaled, intravenous and oral administration in healthy participants.

AIM Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open-label, two-part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (...

C. Riff, Peter Bold, M. Heijer et al. · 0 citations
Clinical trial Open access Sep 2026

Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics and the Pharmacokinetics of Balcinrenone When Dosed with a P‐gp Inhibitor

Dosing of balcinrenone/dapagliflozin without regard to food supports dosing of balcinrenone/dapagliflozin without regard to food, and balcinrenone is not considered a sensitive P‐gp substrate.

A. Eriksson, D. Karsanji, Amy H. Shi et al. · 0 citations

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