482. Altered GABAb receptor–mediated cortical inhibition in heavy alcohol use: evidence from a pharmaco-TMS study using baclofen
Dose- and group-dependent modulation of GABAbR-mediated cortical inhibition by baclofen is demonstrated, and LICI emerges as a sensitive, non-invasive biomarker of GABAbR function and pharmacodynamic target engagement, with potential utility for stratifying neurobiological heterogeneity and informing the development of...