Author

M. Higgins

2 papers indexed here

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Open access Sep 2026

Evolutionary adaptation of helminth immunomodulators to their hosts

Background Parasitic nematodes have evolved secreted effector proteins which interact with host molecules to modulate the host immune response. These interactions can be highly specific and are under strong selective pressure. Here, we investigate the host-pathogen interaction between Heligmosomoides bakeri and its nat...

Beatrice Ward, Abhishek Jamwal, Florent Colomb et al. · bioRxiv · 1 citation

Open access Aug 2026

An African trypanosome surface protein inhibits amplification of the complement system

African trypanosomes replicate within the blood and tissue spaces of their mammalian hosts. As extracellular pathogens, they are constantly exposed to immune cells and molecules and are susceptible to killing by components of the complement system. In this study, we conducted a large-scale screen of a panel of human co...

Alex Cook, Helena Webb, Nicola Minshal et al. · bioRxiv · 0 citations