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Hereditary Diffuse Gastric Cancer With Poorly Differentiated Gallbladder Adenocarcinoma: A Case Report Suggesting Carcinogenesis in the Stomach and Gallbladder Caused by a Pathogenic Germline Variant in CDH1
Background/Aim: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome primarily characterized by a high lifetime risk of diffuse gastric cancer and lobular breast cancer. It is predominantly caused by inactivating germline variants in the tumor suppressor gene CDH1. While the association bet...
Intensive Endoscopic Resection for Downstaging of Superficial Non‐ampullary Duodenal Epithelial Tumor Burden in Familial Adenomatous Polyposis: A Single‐center Retrospective Study on Long‐term Clinical Outcome
ABSTRACT Background and Study Aims Familial adenomatous polyposis (FAP) is a genetic condition that increases the risk of developing colorectal polyposis and cancer, as well as superficial non‐ampullary duodenal epithelial tumors (SNADETs). In this single‐center retrospective study, we investigated the long‐term clinic...