Open access
Aug 2026
Pseudotime analysis of 2,106 brains across nine regions reveals conserved immune, neuronal, and myelin regulatory programs in Alzheimer’s disease
A conserved transcriptional architecture underlying AD progression is revealed, organized around coordinated immune activation, synaptic loss, and myelin remodeling, with the cerebellum following a distinct trajectory.
F. Ecca, S. Song, M. Naymik et al.
· bioRxiv · 0 citations