Author

M. Hussein

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Sep 2026

Integrated Experimental and Computational Evaluation of Silymarin Nanoparticles: Apoptosis Induction, EMT Reversal, and Cell Cycle Arrest in A431 Epidermoid Carcinoma Cells

Cancer remains a major global health challenge. Silymarin-based nanoparticles offer a promising, safer platform for next-generation anticancer therapies. The present study was designed to investigate the cytotoxic and apoptotic potential of silymarin nanoparticles (Sil-NPs) in A431 epidermoid carcinoma cells and to...

Enas Abdallah Elsayed, M. Hussein, A. Fayed et al. · Current Bioactive Compounds · 0 citations

Jul 2026

Innovative Anti-Obesity Strategy: Moringa peregrina Seed Extract-Stabilized Selenium Nanoparticles for Comprehensive Metabolic Health Improvement

The obesity epidemic poses a global challenge that requires safer, natural- based therapeutic alternatives. Here, we present a nanobiotechnology strategy by employing Moringa peregrina (MP) seed extract for the energy-efficient synthesis of stabilized selenium nanoparticles (MPS-SeNPs) and demonstrate their anti-ob...

Tarek Fekry, Hala O Ramadan, M. Hussein et al. · The Natural Products Journal · 0 citations

Aug 2026

Boswellic Acid-Nanoparticles (BA-NPs) Confer Synergistic Hepatoprotection against Paracetamol-Induced Toxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Results indicate that BA- NPs prepared by Span 60/Tween 80 emulsification provide potent hepatoprotection against paracetamol- induced liver injury through synergistic, multi- mechanistic action, significantly protecting against hepatic injury by concurrently suppressing oxidative stress, inflammatory signaling pathway...

Ola Abdallah Ahmed, M. Hussein, Azza Mahmoud Abdullah · The Natural Products Journal · 0 citations

Jul 2026

Green-synthesized Salvia officinalis-conjugated Selenium Nanoparticles Mitigate Diabetic Complications via Multi-target Molecular and Histopathological Restoration in STZ-induced Mice

The results of this study showed that the SeNPs synthesized by SOLE extract have notable antidiabetic and antioxidant activities, which implies a combination of selenium bioactivity and some other phytochemical compounds in S. officinalis.

M. Mansour, M. Hussein, N. Mostafa et al. · Current Bioactive Compounds · 0 citations

Jul 2026

Lapachol Nanoparticles Mitigate Mercuric Chloride-induced Pulmonary Toxicity via Modulation of Oxidative Stress, Inflammatory Signaling, and Nrf2/P39 Pathways

LaP-NPs efficiently prevent HgClⁿ-induced lung injury by inhibiting oxidative stress, modulating stress-related genes, and reducing inflammatory pathways, suggesting that LaP-NPs could serve as a nanotherapeutic for heavy metal-induced pulmonary toxicity.

Azza M. Metwaly, Manar Eldeeb, M. Hussein et al. · Current Bioactive Compounds · 0 citations