New quinazoline derivatives with anti-inflammatory activity and computationally predicted PDE7A binding: synthesis, molecular modeling, and in silico pharmacokinetic evaluation
Quinazoline scaffolds are widely recognized in drug discovery for their diverse pharmacological profiles, and several quinazoline derivatives have been reported as phosphodiesterase 7A (PDE7A) inhibitors with potential anti-inflammatory effects. This study aimed to synthesize novel quinazoline derivatives, evaluate the...