Author

M. Javle

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Review Sep 2026

Personalized Therapy in Advanced Cholangiocarcinoma: Contemporary Treatment Approaches and Future Directions.

Cholangiocarcinoma (CCA) includes a heterogeneous group of malignancies arising from the biliary epithelium, anatomically classified into intrahepatic, perihilar, and distal disease, with subtype-specific molecular features and treatment implications. Intrahepatic CCA is further subclassified into small- and large-duct...

F. Saj, C. B. Xavier, L. Goyal et al. · JCO Oncology Practice · 0 citations

Aug 2026

Clinical, genomic, and spatial transcriptomic features of pancreatic adenosquamous carcinoma support subtype-specific therapeutic strategies.

Despite shared genomic drivers with PDAC, ASQ exhibits transcriptionally distinct features with spatially organized tumor and immune heterogeneity, supporting the need for subtype-specific therapeutic strategies.

S. Haldar, Meredith Wetzel, Jia-Yun Lu et al. · Clinical Cancer Research · 0 citations

Open access Aug 2026

Proteogenomic profiling identifies FGFR2b as a prevalent cell-surface target in intrahepatic cholangiocarcinoma.

This approach identified a unique peptide corresponding to FGFR2b, a splicing isoform of FGFR2, that demonstrated markedly higher tumor enrichment than the alternative FGFR2 isoform, FGFR2c.

N. Shah, Beatriz Alvarado-Hernandez, Xinyue Chen et al. · Clinical Cancer Research · 0 citations