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Author

M. Juonala

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Open access Sep 2026

Multi-national evaluation of low-density lipoprotein cholesterol equations in young adulthood for long-term risk of atherosclerotic cardiovascular disease

Background Accurate low-density-lipoprotein-cholesterol (LDL-C) assessment in young adulthood is critical for atherosclerotic cardiovascular disease (ASCVD) prevention, yet the optimal estimation equation remains uncertain. We compared the Friedewald, Martin-Hopkins, and Sampson equations for evaluating long-term ASCVD...

Ya-Xing Meng, Fei-Tong Wu, M. Juonala et al. · 1 citation
Open access Sep 2026

Lipoprotein(a): Particle vs mass and prevalent cardiovascular disease in the cardiovascular risk in Young Finns study population.

BACKGROUND Lipoprotein(a) [Lp(a)] can be reported as mass (mg/dL) or particle concentration (nmol/L). Because Lp(a) acts at the particle level, molar concentration may better reflect biologically relevant exposure. OBJECTIVE To compare molar- and mass-based Lp(a) in relation to cardiovascular outcomes, risk classific...

O. Raitakari, M. Knuuti, A. Linko-Parvinen et al. · 0 citations
Open access Aug 2026

Ultrasound-detected fatty liver in young adults and long-term risk of atherosclerotic cardiovascular disease: The Young Finns Study.

BACKGROUND Fatty liver is the most common chronic liver disease globally and is associated with increased cardiovascular risk. Evidence specifically addressing fatty liver and cardiovascular outcomes in young adults from European population-based cohorts remains scarce. METHODS Fatty liver was assessed by abdominal u...

O. Raitakari, K. Pahkala, S. Rovio et al. · 0 citations
Open access Aug 2026

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood factors and polygenic risk scores (PRSs). Data fro...

Rooholla Poursoleymani, Ioannis Papathanail, Lorenzo Brigato et al. · 0 citations
Open access Sep 2026

Associations of lipoprotein(a) with fasting insulin, fasting glucose, and incident type 2 diabetes: a prospective analysis from the Young Finns Study

Inverse associations between Lp(a) and fasting glucose were observed in males and higher adult Lp(a) concentrations were prospectively associated with lower risk of incident type 2 diabetes, in the prospective Young Finns Study cohort.

M. Knuuti, N. Kartiosuo, K. Pahkala et al. · 0 citations
Open access Aug 2026

Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

An LE8-derived DNAm score was associated with lower cIMT across the life course and, to a lesser extent, across generations, suggesting that blood DNAm reflects cumulative cardiovascular health and vascular burden and may complement conventional cardiovascular risk assessment.

B. Mishra, E. Raitoharju, L.-P. Lyytikäinen et al. · 0 citations

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