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Open access Oct 2026

A Multi-Biomarker Signature of Immune Activation and Metabolic Shift Predicts Treatment Success in Localized Prostate Cancer

A multi-biomarker panel, notably including SDF1, AD, and IL-39, emerges as a promising discovery-phase signature that, following independent external validation, may provide a non-invasive method for monitoring therapeutic response, but further validation is needed before clinical use.

AbdulQader M. AbdulQader, M. K. Abd, Kawthar Amer al-Shamari et al. · 0 citations
Open access Aug 2026

De Novo Design and Molecular Dynamics Evaluation of AZ67-Derived Allosteric PFKFB3 Modulators for Anticancer Metabolic Drug Discovery

PFKFB3 is a druggable regulator of fructose-2,6-bisphosphate production, glycolytic flux, angiogenic metabolism, and tumour-cell survival signalling. This study redesigned the AZ67 allosteric scaffold to prioritise computational leads for anticancer metabolic drug discovery. ChemoDOTS enumeration produced 575,760 virtu...

A. Mohammed, Jameelah K. T. Al-Isawi, M. K. Abd · 0 citations

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