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Open access Oct 2026

Blood biomarkers identified with multi-omics combined with clinical and muscle imaging in oculopharyngeal muscular dystrophy

Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset, slowly progressive muscular dystrophy characterized by dysphagia, eyelid ptosis, and proximal limb weakness. Clinical trial readiness in OPMD requires development of sensitive indicators of disease progression and potential response to therapies in de...

I. Smith, Matthew Triolo, Karim Karimi et al. · 0 citations
Open access Sep 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Findings show that multiple resistance-associated programs spanning signaling, cell survival, and metabolism share a dependency on eIF4A-dependent translation and provide a preclinical rationale to test whether adding eIF4A inhibition can prolong responses to MAPK-targeted therapy in melanoma.

Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al. · 0 citations

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