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M. Khayat

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Open access Sep 2026

Synthesis, in vitro and in silico evaluation of quinazoline and triazoloquinazoline derivatives as PDE7A inhibitors

Background and purpose: Phosphodiesterase 7A (PDE7A) is an attractive therapeutic target for the treatment of inflammatory, autoimmune, and neurodegenerative disorders through modulation of intracellular cAMP levels. However, the development of highly potent and selective PDE7A inhibitors remains challenging. This stud...

Afaf A. El-Malah, M. M. Gineinah, M. Khayat et al. · 0 citations

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