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Open access Sep 2026

N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure

Exercise and cold exposure elicit partly overlapping metabolic adaptations through distinct mechanisms. Here, we sought to identify circulating factors shared by these stimuli. We found that exercise and cold exposure upregulated thrombospondin-1 (TSP1) expression in skeletal muscle and brown adipose tissue (BAT) and i...

M. Kim, Hyun-Jun Jang, Jae Sook Kang et al. · 0 citations
Review Open access Sep 2026

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

ABSTRACT Skeletal muscle aging is increasingly recognized as a failure of tissue‐level coordination rather than a consequence of isolated defects in individual cell types. Recent advances in single‐cell, spatial, and multimodal omics have revealed that aging remodels the abundance, functional states, and interactions o...

Seongwan Kim, M. Kim, Yong Ryoul Yang · 0 citations

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