M. Kjaergaard

Affinity and distance dependence of SLiM-mediated dephosphorylation by protein phosphatase 1

Protein phosphatases counterbalance kinases by dephosphorylating phospho-proteins to regulate signaling pathways. But unlike kinases, their shallow catalytic groove has limited selectivity for the phospho-peptide motifs. Phosphatases such as protein phosphatase-1 (PP1) recognize their substrates through short linear mo...