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Author

M. Königsberg

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Open access Oct 2026

Impaired autophagy and lysosome function in human fibroblast aging

Human aging is characterized by a progressive, time-dependent deterioration in physiological and cognitive functioning. Aging is driven by an array of interconnected cellular hallmarks, including genomic instability, mitochondrial dysfunction, telomere attrition, epigenetic alteration and dysfunctional autophagy. A...

Juan José Unzueta-Mendoza, I. García-Aguirre, M. Königsberg et al. · 0 citations
Open access Oct 2026

Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats

Sleep restriction is associated with neuroinflammation, blood-brain barrier (BBB) dysfunction, and cognitive impairment. Although reduced sleep duration in women is well recognized and the impact of sleep disorders is correlated with a higher incidence of neurodegenerative diseases, its consequences during female aging...

Ana B. Ramírez-López, Jessica J. Avilez-Avilez, B. Gómez-González et al. · 0 citations

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