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Two novel large AIP deletions are reported here and three additional three families, including an Albanian kindred associated with metastatic Hürthle cell thyroid carcinoma, are reported, including an Albanian kindred associated with metastatic Hürthle cell thyroid carcinoma.
Novel genes and miRs are revealed in NF-PitNETs suggesting their potential regulatory role in cell adhesion, migration, and apoptosis therefore potentially contributing to their pathogenesis.
Context Somatotrophinomas can occasionally occur in familial settings and may be associated with known germline mutations, such as MEN1, AIP, CDKN1B, PRKAR1A, SDHx, and MAX. Recently, the CHEK2 gene has emerged as a potential pituitary tumour predisposition gene. Objective To present a rare case of a patient with a pit...
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