Open access
Oct 2026
Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction
Francesca Solagna, D. Martínez-Martínez, Norma Gabriela Zavala-Torres et al.
· bioRxiv · 0 citations
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Open access
Sep 2026
Role of Nuclear SUMO-Targeted Ubiquitin Ligase Uls2 (Slx5-Slx8) in Quality Control of Cytosolic Proteins
The interplay between the posttranslational modifiers SUMO and ubiquitin mediates the degradation of proteins. This crosstalk is conveyed by SUMO-targeted ubiquitin ligases (STUbLs). The best-studied STUbL in Saccharomyces cerevisiae is the heterodimer Slx5-Slx8 (Uls2). Uls2 mainly resides in the nucleus and is involve...
Friederike Profe-Austermann, Lennard-Maximilian Döring, L. Schmidt et al.
· Biomolecules · 0 citations
Open access
Sep 2026
Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm
Morphological studies of the diaphragm have provided a detailed view of its architecture, which consists of parallel skeletal muscle fibers and a central ring of neuronal innervation that includes neuromuscular junction (NMJ) units. NMJs are disease-vulnerable synapses; thus, analysis of the NMJ is essential to underst...
Nitin Eapen, L. Schmidt, M. Saynisch et al.
· Communications Biology · 0 citations
Open access
Aug 2026
Antisense oligonucleotide selection scheme for rare Duchenne muscular dystrophy mutations: Application to DMD exon 16 skipping
The feasibility of developing a safe and effective lead compound with efficient exon 16 skipping, favorable pharmacokinetic and safety profiles, able to rescue dystrophic transcriptomic and proteomic signatures is demonstrated.
Marine Geoffroy-Guiraud, C. Beley, Stephany Campuzano et al.
· Molecular Therapy: Nucleic A... · 0 citations