Serum metabolomics modelling reveals stage-associated purine and endocannabinoid metabolic signatures in colorectal cancer progression
Background Colorectal cancer (CRC) remains one of the major challenges in contemporary oncology. Despite advances in imaging diagnostics and histopathological assessment, we still lack tools for the early detection of micrometastases and molecular alterations. The purinergic and endocannabinoid systems play an importan...