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Author

M. Kulecka

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Open access Sep 2026

Early Hepatic Transcriptomic Responses to High-Fat Diet in Apolipoprotein A-IV Knockout Mice

Background: Apolipoprotein A-IV (ApoA-IV) is involved in lipid metabolism and energy homeostasis, but its role in hepatic adaptation to dietary stress remains incompletely understood. This study aimed to determine whether ApoA-IV deficiency alters hepatic transcriptional responses to high-fat diet (HFD) and to examine...

N. Żeber-Lubecka, M. Kulecka, K. Pyśniak et al. · 0 citations
Open access Aug 2026

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Findings identify CDK8 as a transcriptional node of LSC-associated programs and provide a mechanistic rationale for combined CDK8-BET inhibition in molecularly defined AML subsets, which will require validation in functional LSC assays and primary specimens.

M. Statkiewicz, I. Rumieńczyk, U. Pakulska et al. · 0 citations

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