Drug-in-Cyclodextrin-in-Liposome Hybrid Systems for Hydrophobic Drug Delivery: A Comprehensive Review.
Delivering hydrophobic active pharmaceutical ingredients remains a major challenge due to poor aqueous solubility, limited bioavailability, and chemical instability. Drug-in-cyclodextrin-in-liposome (DCL) technology combines cyclodextrin inclusion complexation with liposomal encapsulation to address these limitations....