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Author

M. Larcher

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Open access Sep 2026

CReP-mediated control of eIF2α phosphorylation is a critical node in MYC-driven medulloblastoma

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The MYC‑amplified group 3 (G3) MB represents a high‑risk disease lacking effective therapies. A genetic screen identified the endoplasmic reticulum chaperone HSPA5 (BiP/GRP78) as a critical dependency in G3 MB. Its silencing induces apoptosis and...

Liliana Mirabal-Ortega, Sandra Majo, Lucie J. Taunay et al. · 0 citations

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