Author

M. Lim-Fat

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Review Open access Aug 2026

Exclusion of patients with brain metastases from early-phase systemic therapy trials: a cross-sectional analysis of eligibility criteria

Patients with brain metastases (BrM) are frequently excluded from early-phase clinical trials, limiting evaluation of central nervous system (CNS) efficacy of novel therapies. We aimed to determine the proportion of phase I systemic therapy trials for patients with metastatic solid tumours that permit enrolment of pati...

C. Zatzman, I. Fernandes, I. Kojundzic et al. · Journal of Neuro-Oncology · 0 citations

Review Open access Sep 2026

Next-generation therapeutics for glioblastoma: Challenges and future directions

This review summarizes the evolving molecular landscape of glioblastoma and examines emerging therapeutic approaches designed to overcome barriers, and discusses advances in molecularly targeted therapies, including strategies directed at BRAF and FGFR alterations, as well as continued efforts to address EGFR-driven di...

J. Blaquier, M. Lim-Fat, M. I. de la Fuente · Neurotherapeutics · 0 citations