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Open access Aug 2026

Association of depressive symptoms with sweat chloride variability and medication possession ratio during long-term Elexacaftor/Tezacaftor/Ivacaftor therapy in adolescents and young adults with cystic fibrosis

Introduction Elexacaftor/tezacaftor/ivacaftor (ETI) sustainably improves lung function (FEV₁), quality of life and sweat chloride (SC) levels in people with cystic fibrosis (pwCF). Psychological comorbidities may impair treatment adherence. This study assessed ETI adherence using SC and medication possession ratio (MPR...

M. Lorenz, M. Pavlova, Katja Erler et al. · 0 citations
Open access Sep 2026

Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial

Summary Background Preschool children with asthma are more susceptible to develop acute life-threatening respiratory distress leading to hospital admissions compared to school children and treatment options are limited for this age group. We evaluated the safety and efficacy of tiotropium as add-on therapy to inhaled c...

S. Zielen, N. Wollscheid, T. Nickolay et al. · 0 citations

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