Continued remission maintained with decitabine monotherapy in an elderly patient with TP53 multi-hit acute myeloid leukemia relapsed after allogeneic transplantation.
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Simple Summary Epigenetic alterations accumulate throughout life in hematopoietic stem and progenitor cells (HSPCs), leading to an increased risk of acute myeloid leukaemia (AML). Here, we investigated whether targeting the methylation of histone 3 at lysine 9 (H3K9 methylation) affects HSPCs upon aging and leukemogene...
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