Understanding neuro-glial roles in homeostasis and disease requires scalable central nervous system (CNS) models, particularly as macroglia like astrocytes and Müller glia remain challenging to study in slow-developing human systems. Here, we generate and map the cellular diversity of mouse neural organoids spanning mu...
A single-cell CRISPR screening platform is established in gastruloids to identify Cnot8-dependent mRNA deadenylation as a driver of mesoderm patterning and identify the deadenylase Cnot8 as a fundamental mechanism linking cellular identity with morphogenetic signaling during mammalian body plan formation.
D. Taborsky, Fabiola Valdivia-Francia, Pablo Serrano et al.· Nature Communications· 0 citations
ABSTRACT Cell state, growth, and mechanics are tightly connected properties underpinned by fundamental biological processes. Yet methods to quantify them simultaneously under physiologically relevant conditions, at resolutions sufficient to follow (sub)cellular processes, are still lacking. In particular, the correlati...
Ilaria Incaviglia, Giulia E. M. Ammirati, S. Herzog et al.· Advancement of science· 0 citations
Clinical translation of T cell bispecific (TCB) therapies in solid tumors is hindered by the immunosuppressive tumor microenvironment and intratumoral heterogeneity, features poorly captured by standard preclinical models. We applied an integrated translational framework, combining humanized mouse models, a patient-d...
Sabine Wilson, Abraham Silva, M. Serrano-Serrano et al.· npj Precision Oncology· 0 citations
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