Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodological approaches - from target trial emulati...
T. Formánek, M. Lynall, E. Osimo· The British journal of psych...· 0 citations
Neurodevelopmental and psychiatric conditions have long been hypothesised to emerge from changes in the structure and function of the brain. However, the molecular and cellular mechanisms linking brain structure to these conditions remain unknown. Here, using genetic and structural/diffusion neuroimaging data from 59,2...
Y. He, A. Ebneabbasi, K. Rademaker et al.· medRxiv· 0 citations
Abstract Background A challenge for developing new major depressive disorder (MDD) treatments is understanding how non-heritable risk factors like stress alter biological processes. We previously used preclinical animal models to demonstrate chronic psychosocial stress reorganizes the peripheral and meningeal immune mi...
S. Kigar, X. Shen, S. White et al.· International Journal of Neu...· 0 citations
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