Plasma multiplex proteomics identified complementary dimensions of neuroaxonal injury and immune dysregulation across frontotemporal lobar degeneration-related syndromes and candidates for independent biomarker validation and mechanistic investigation are identified.
M. van Schaik, K. O. Lai, N. Shapiro et al.· medRxiv· 0 citations
Dementia with Lewy Bodies (DLB) is the most common neurodegenerative dementia after Alzheimer’s disease (AD), but it remains challenging to diagnose due to overlapping symptoms and mixed pathologies. This pilot study tested whether DLB has different metabolic blood proteomic profiles compared to AD and controls. Serum...
Ariana Pritha, L. Chouliaras, P. Swann et al.· International Journal of Mol...· 0 citations
Examination of blood-based T-cell profiles across a range of neurodegenerative dementias provides evidence that T-cell dysregulation is not unified in patients with neurodegenerative diseases and observes different involvement across different dementia types establishing adaptive immunity as a key contributor to diseas...
Frederika Malichova, P. Swann, S. Kigar et al.· Alzheimer's Research & Thera...· 0 citations
Sex and educational attainment significantly affect the development and maintenance of cognitive reserve in individuals with genetic FTD, and underscore the importance of identifying disease-modifying interventions since the presymptomatic stages of the disease.
E. Premi, Damiano Archetti, A. Redolfi et al.· Brain Communications· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
A multivariate blood-based framework integrating 19 molecular assays and six risk instruments in the Bio-Hermes-001 cohort supports resilience and resistance as molecularly distinct subgroups and provides a scalable framework for pathology-informed stratification and mechanistic investigation.
K. Mavromati, C. Dalby, A. Dibble et al.· medRxiv· 0 citations
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