ABSTRACT The acute respiratory distress syndrome (ARDS) is fundamentally characterized by alveolar injury, leading to lung edema, severe hypoxemia, and poorly compliant lungs. Alveolar and cardiovascular pathology are deeply intertwined in the syndrome, which can be marked by clinical cardiac, pulmonary, and systemic v...
P. A. Sanchez, Connor G. O'Brien, M. Legrand et al.· Comprehensive Physiology· 0 citations
Sepsis is the leading cause of acute kidney injury in critically ill patients, and this complication carries a high risk of death. The biology underlying it varies between patients, which may explain why treatments have not succeeded. Here we show, using an ensemble method that groups patients by patterns across hundre...
M. Legrand, H. Nguyen, C. Calfee et al.· Nature Communications· 0 citations
GDF15 is a biomarker of mitochondrial metabolic dysfunction and is prognostic across three trial populations of sepsis and ARDS, but it was not independently associated with mortality in a smaller observational cohort, and is a candidate for prognostic enrichment in trials of metabolically targeted therapies, though wh...
N. Alipanah-Lechner, Carolyn Leroux, A. Ringor et al.· Critical Care· 0 citations
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