HP1 can act independently of H3K9 methylation to promote heterochromatin focus formation, gene repression, and organogenesis.
Histone post-translational modifications (PTMs) segregate genomes into heterochromatin and euchromatin by recruiting readers, such as Heterochromatin Protein 1, which binds methylation of histone H3 lysine 9 (H3K9me). Here, we report H3K9me-independent functions for the C. elegans HP1 orthologue HPL-2 and the H3K9 meth...