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Author

M. Molina-Vila

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Open access Sep 2026

Understanding tumor adaptations and resistance to MET inhibitors in MET-altered non-small cell lung cancer

Highlights • MET inhibitor resistance is heterogeneous across distinct MET-altered NSCLC.• Spatial transcriptomics reveal shared ECM remodeling in tumors upon progression.• In vitro models partially recapitulate aspects of clinical MET inhibitor resistance.• CRISPR and combination drug screens reveal overlapping functi...

M. Simard, E. Marin, S. García-Román et al. · 0 citations
Review Open access Aug 2026

Tumor microenvironment and signaling pathways in melanoma brain metastasis

Melanoma has one of the highest propensities to metastasize to the brain, and despite major advances with immune checkpoint inhibitors, brain metastases remain a leading cause of morbidity and mortality. The biological mechanisms governing brain colonization, immune evasion, and resistance to therapy are incompletely u...

R. Rosell, M. González-Cao, D. Olmo-Gónzalez et al. · 0 citations
Open access Aug 2026

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

In the H2030 xenograft model, tumor growth was significantly inhibited by treatment with the three-drug combination of omeprazole, sotorasib, and selinexor, with no apparent toxic side-effects or weight loss observed.

Jessica González, Xue-Ting Cai, Wenjing Diao et al. · 0 citations

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