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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. A. Nakasone

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Open access Jul 2026

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC

A molecular glue-stabilizer and PROTAC strategies are combined to enable ubiquitination of the 14-3-3/estrogen receptor α complex, revealing cooperative linker-dependent activity and a structural basis for targeted E3 ligase recruitment.

Carlo J. A. Verhoef, Charlotte Crowe, M. Nakasone et al. · 0 citations

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